Pak2 protein (Mus musculus) - STRING interaction network

Pak2 protein (Mus musculus) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	Pak2	p21 (CDKN1A)-activated kinase 2; The activated kinase acts on a variety of targets. Full length PAK 2 stimulates cell survival and cell growth. The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD. Caspase-activated PAK-2p34 is involved in cell death response, probably involving the JNK signaling pathway (By similarity) (524 aa)
		(Mus musculus)
Predicted Functional Partners:
	Arhgef7	Rho guanine nucleotide exchange factor (GEF7); Acts as a RAC1 guanine nucleotide exchange facto [...] (741 aa)		•	•	•		0.983
	Cdc42	cell division cycle 42 homolog (S. cerevisiae); Plasma membrane-associated small GTPase which c [...] (191 aa)			•	•		0.980
	Nck1	non-catalytic region of tyrosine kinase adaptor protein 1 (377 aa)		•	•	•		0.960
	Casp3	caspase 3; Involved in the activation cascade of caspases responsible for apoptosis execution. [...] (277 aa)			•	•		0.959
	Vav2	vav 2 oncogene; Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases (B [...] (868 aa)			•	•		0.936
	Rac2	RAS-related C3 botulinum substrate 2; Plasma membrane-associated small GTPase which cycles betw [...] (192 aa)			•	•		0.930
	Vav1	vav 1 oncogene; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thu [...] (845 aa)			•	•		0.920
	Grb2	growth factor receptor bound protein 2; Adapter protein that provides a critical link between c [...] (217 aa)			•	•		0.916
	Fyn	Fyn proto-oncogene; Implicated in the control of cell growth. Plays a role in the regulation of [...] (537 aa)			•	•	•	0.905
	Pak3	p21 (CDKN1A)-activated kinase 3; Key regulator of synapse formation and plasticity in the hippo [...] (559 aa)	•	•	•	•	•	0.905

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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