node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACE | AGT | ENSGALP00000039731 | ENSGALP00000018089 | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | Angiotensinogen; Belongs to the serpin family. | 0.985 |
ACE | NR3C2 | ENSGALP00000039731 | ENSGALP00000058137 | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity). | 0.724 |
AGT | ACE | ENSGALP00000018089 | ENSGALP00000039731 | Angiotensinogen; Belongs to the serpin family. | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | 0.985 |
AGT | NR3C2 | ENSGALP00000018089 | ENSGALP00000058137 | Angiotensinogen; Belongs to the serpin family. | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity). | 0.685 |
BDNF | NR3C1 | ENSGALP00000071950 | ENSGALP00000052544 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Uncharacterized protein. | 0.470 |
BDNF | NR3C2 | ENSGALP00000071950 | ENSGALP00000058137 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity). | 0.680 |
FKBP4 | FKBP5 | ENSGALP00000070868 | ENSGALP00000067232 | Peptidylprolyl isomerase. | Peptidylprolyl isomerase. | 0.578 |
FKBP4 | HSP90AA1 | ENSGALP00000070868 | ENSGALP00000060285 | Peptidylprolyl isomerase. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.863 |
FKBP4 | NR3C1 | ENSGALP00000070868 | ENSGALP00000052544 | Peptidylprolyl isomerase. | Uncharacterized protein. | 0.943 |
FKBP4 | NR3C2 | ENSGALP00000070868 | ENSGALP00000058137 | Peptidylprolyl isomerase. | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity). | 0.860 |
FKBP4 | PGR | ENSGALP00000070868 | ENSGALP00000027736 | Peptidylprolyl isomerase. | Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.917 |
FKBP4 | PTGES3 | ENSGALP00000070868 | ENSGALP00000069892 | Peptidylprolyl isomerase. | Prostaglandin E synthase 3; Molecular chaperone. | 0.947 |
FKBP5 | FKBP4 | ENSGALP00000067232 | ENSGALP00000070868 | Peptidylprolyl isomerase. | Peptidylprolyl isomerase. | 0.578 |
FKBP5 | HSP90AA1 | ENSGALP00000067232 | ENSGALP00000060285 | Peptidylprolyl isomerase. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.869 |
FKBP5 | NR3C1 | ENSGALP00000067232 | ENSGALP00000052544 | Peptidylprolyl isomerase. | Uncharacterized protein. | 0.966 |
FKBP5 | NR3C2 | ENSGALP00000067232 | ENSGALP00000058137 | Peptidylprolyl isomerase. | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity). | 0.778 |
FKBP5 | PGR | ENSGALP00000067232 | ENSGALP00000027736 | Peptidylprolyl isomerase. | Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.842 |
FKBP5 | PTGES3 | ENSGALP00000067232 | ENSGALP00000069892 | Peptidylprolyl isomerase. | Prostaglandin E synthase 3; Molecular chaperone. | 0.949 |
HSD11B2 | NR3C1 | ENSGALP00000042090 | ENSGALP00000052544 | Hydroxysteroid 11-beta dehydrogenase 2. | Uncharacterized protein. | 0.554 |
HSD11B2 | NR3C2 | ENSGALP00000042090 | ENSGALP00000058137 | Hydroxysteroid 11-beta dehydrogenase 2. | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity). | 0.785 |