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This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
Ptpn6
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase SHP-1); Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation (555 aa)
(Rattus norvegicus)
Predicted Functional Partners:
Jak2
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2); Tyrosine kinase of the non [...] (1132 aa)
    ••• 0.967
Src
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src) (536 aa)
     •••0.931
Cd72
CD72 antigen (364 aa)
    ••• 0.927
Grb2
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein A [...] (216 aa)
    ••••0.925
Egfr
epidermal growth factor receptor (1209 aa)
    ••• 0.924
Egf
Pro-epidermal growth factor precursor (EGF) [Contains- Epidermal growth factor]; EGF stimulates [...] (1132 aa)
     •• 0.921
ENSRNOG00000017879
annotation not available (694 aa)
    ••• 0.919
Zap70
zeta-chain (TCR) associated protein kinase 70 (614 aa)
    ••• 0.917
Fyn
Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn); Implicated in the control o [...] (537 aa)
     •••0.915
Csk
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase); Specifically phosphorylates 'Tyr-504' [...] (450 aa)
     •••0.909
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.
Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:
additional (white) nodes         or: network depth