STRINGSTRING
ADAM32 ADAM32 IZUMO2 IZUMO2 IZUMO4 IZUMO4 PLEKHA2 PLEKHA2 ADAMTSL3 ADAMTSL3 C19orf71 C19orf71 ZPBP2 ZPBP2 TEX55 TEX55 PLPP5 PLPP5 TSACC TSACC C2CD6 C2CD6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ADAM32Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein. (787 aa)    
Predicted Functional Partners:
IZUMO2
Izumo sperm-egg fusion protein 2; IZUMO family member 2.
   
  
 0.572
IZUMO4
Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family.
      
 0.535
PLEKHA2
Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity).
 
    
 0.515
ADAMTSL3
ADAMTS-like protein 3; ADAMTS like 3.
   
  
 0.476
C19orf71
Uncharacterized protein C19orf71; Chromosome 19 open reading frame 71.
      
 0.464
ZPBP2
Zona pellucida-binding protein 2; Is implicated in sperm-oocyte interaction during fertilization.
   
  
 0.464
TEX55
Testis expressed 55.
   
  
 0.462
PLPP5
Phospholipid phosphatase 5; Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules.
   
  
 0.456
TSACC
TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family.
   
  
 0.448
C2CD6
C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6.
   
  
 0.441
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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