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This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
SPAM1
Hyaluronidase PH-20 precursor (EC 3.2.1.35) (Hyal-PH20) (Sperm surface protein PH-20) (Sperm adhesion molecule 1); Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid (511 aa)
(Homo sapiens)
Predicted Functional Partners:
IDUA
Alpha-L-iduronidase precursor (EC 3.2.1.76) (653 aa)
     •• 0.899
ARSB
Arylsulfatase B precursor (EC 3.1.6.12) (ASB) (N-acetylgalactosamine- 4-sulfatase) (G4S) (533 aa)
     •• 0.899
WWOX
WW domain-containing oxidoreductase isoform 2 (525 aa)
      • 0.857
SPAG9
C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-asso [...] (1313 aa)
      • 0.829
HYAL2
Hyaluronidase-2 precursor (EC 3.2.1.35) (Hyal-2) (Hyaluronoglucosaminidase-2) (LUCA-2); Hydroly [...] (473 aa)
     •••0.820
HYAL1
Hyaluronidase-1 precursor (EC 3.2.1.35) (Hyal-1) (Hyaluronoglucosaminidase-1) (LUCA-1); May hav [...] (435 aa)
     •••0.819
MSH6
DNA mismatch repair protein MSH6 (MutS-alpha 160 kDa subunit) (G/T mismatch-binding protein) (G [...] (1360 aa)
      • 0.801
NAT6
Hyaluronidase-3 precursor (EC 3.2.1.35) (Hyal-3) (Hyaluronoglucosaminidase-3) (LUCA-3); Seems t [...] (608 aa)
      • 0.765
ADAM2
ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) [...] (735 aa)
      • 0.704
ACRV1
Acrosomal protein SP-10 precursor (Acrosomal vesicle protein 1) (265 aa)
      • 0.692
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.
Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:
additional (white) nodes         or: network depth