STRINGSTRING
IRF8 IRF8 BATF3 BATF3 SPI1 SPI1 CSF1R CSF1R XCR1 XCR1 ZBTB46 ZBTB46 TRAK1 TRAK1 CDC34 CDC34 STAT1 STAT1 NFIL3 NFIL3 EFNA5 EFNA5
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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IRF8Interferon regulatory factor 8; Plays a role as a transcriptional activator or repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a regulatory role in cells of the immune system (By similarity); Belongs to the IRF family. (425 aa)    
Predicted Functional Partners:
BATF3
Basic leucine zipper ATF-like transcription factor 3.
   
 
 0.885
SPI1
ETS domain-containing protein.
   
 
 0.745
CSF1R
Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
   
 
 0.738
XCR1
CCXC chemokine receptor 1 like.
   
  
 0.710
ZBTB46
Zinc finger and BTB domain containing 46.
   
 
 0.706
TRAK1
Trafficking kinesin protein 1.
      
 0.679
CDC34
Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.
    
 
 0.671
STAT1
Signal transducer and activator of transcription.
   
 
 0.655
NFIL3
Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator (By similarity). Represses PER2 transcription through a recognition sequence in the promoter. Component of the circadian clock that may contribute to the rhythmic expression of PER2 gene in a light-dependent and time-of-day-dependent manner.
    
 
 0.646
EFNA5
Ephrin-A5; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor t [...]
      
 0.630
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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