version_number_image
 
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
Pik3ca
Phosphatidylinositol 3-kinase alpha catalytic subunit (EC 2.7.1.137) (Fragment) (1074 aa)
(Rattus norvegicus)
Predicted Functional Partners:
Pten
phosphatase and tensin homolog (403 aa)
    ••• 0.972
Akt1
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) [...] (480 aa)
     •• 0.953
Irs1
Insulin receptor substrate 1 (IRS-1) (pp185); May mediate the control of various cellular proce [...] (1235 aa)
    ••• 0.951
Egfr
epidermal growth factor receptor (1209 aa)
     •• 0.945
Pik3r1
Phosphatidylinositol 3-kinase (Fragment); Binds to activated (phosphorylated) protein-Tyr kinas [...] (713 aa)
    ••• 0.930
Pik3r3
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3 [...] (461 aa)
    ••• 0.929
Pdpk1
3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (Protein kinase B kinase) (PkB kina [...] (551 aa)
     •• 0.927
Akt2
RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Pr [...] (481 aa)
     •• 0.923
Egf
Pro-epidermal growth factor precursor (EGF) [Contains- Epidermal growth factor]; EGF stimulates [...] (1132 aa)
     •• 0.923
Pik3r2
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3- [...] (722 aa)
    ••• 0.923
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.
Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:
additional (white) nodes         or: network depth