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cfr1 cfr1 bch1 bch1 gga22 gga22 gga21 gga21 apm1 apm1 kha1 kha1 vps10 vps10 trk2 trk2 fsv1 fsv1 sst4 sst4 pvg3 pvg3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
cfr1Cell fusion protein cfr1; Required for cell fusion, independently of fus1. Appears to have a role in transporting proteins that are involved in mating. May act as a scaffold to retain cell fusion proteins in the cisternae of the Golgi. Degraded at the onset of mating and this leads to release of cell fusion proteins; Belongs to the CHS5 family. (620 aa)    
Predicted Functional Partners:
bch1
Uncharacterized protein C31F10.16.
    
 0.969
gga22
Probable ADP-ribosylation factor-binding protein C25H2.16c; May play a role in the regulation of membrane traffic through the trans-Golgi network; Belongs to the GGA protein family.
   
 
 0.832
gga21
Probable ADP-ribosylation factor-binding protein C1F3.05; May play a role in the regulation of membrane traffic through the trans-Golgi network.
   
 
 0.815
apm1
AP-1 complex subunit mu-1; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity).
    
 
 0.794
kha1
K(+)/H(+) antiporter 1; Potassium-proton antiport; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
   
  
 0.748
vps10
Vacuolar protein sorting/targeting protein 10; Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment; Belongs to the VPS10-related sortilin family.
   
  
 0.631
trk2
Potassium transport protein 2; Together with TRK1, defines the major, high-affinity potassium influx transport system. Involved in maintenance of the proper sodium/potassium ratio in the cell and in regulating the plasma membrane potential.
      
 0.629
fsv1
Syntaxin-like protein fsv1; Involved in vesicle-mediated protein transport between the Golgi and the vacuole.
   
  
 0.537
sst4
Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
    
 
 0.532
pvg3
Beta-1,3-galactosyltransferase pvg3; Involved in cell wall biogenesis. Has a role in the addition of Gal-beta1,3 moeities to galactomannans and their subsequent pyruvylation. Has a role in meiosis.
   
    0.511
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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