node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PufA | acbA | Q54WA7 | Q5FXM5 | RNA binding protein. | Acyl-CoA-binding protein; Binds to acyl-CoA. Processed into the SDF-2 (spore differentiation factor 2) a peptide which triggers sporulation. SDF-2 appears to stimulate prestalk cells to release additional SDF-2 by acting through a signal transduction pathway that also involves dhkA, regA and PKA. Induces encapsulation of prespore cells in a dhkA- dependent manner. GABA induces the release of acbA from prespore cells and induces the exposure of tagC on the surface of prestalk cells where it can convert acbA to SDF-2. Glutamate acts as a competitive inhibitor and is also able to inhibit [...] | 0.423 |
PufA | acgA | Q54WA7 | Q03101 | RNA binding protein. | Adenylate cyclase, germination specific; Has a large extracellular domain which may be involved in the recognition of an extracellular signal present during germination, leading to activation or inhibition of cAMP synthesis by the cytoplasmic domain. | 0.524 |
PufA | dhkC | Q54WA7 | Q95PI2 | RNA binding protein. | Hybrid signal transduction histidine kinase C; Acts in a signal transduction pathway that regulates the slug versus culmination choice. Believed to be the first component of a phosphorelay that couples the sensing of ammonia to the modulation of PKA activity and hence activates culmination and spore germination. Ammonium transporters amtA and amtC are thought to respectively activate and inhibit dhkC phosphorelay. This protein probably undergoes an ATP-dependent autophosphorylation at conserved His residue in the kinase core, and a phosphoryl group is then transferred to a conserved as [...] | 0.457 |
PufA | pkaR | Q54WA7 | P05987 | RNA binding protein. | cAMP-dependent protein kinase regulatory subunit. | 0.418 |
PufA | tagC | Q54WA7 | Q23868 | RNA binding protein. | Serine protease/ABC transporter B family protein tagC; May be directly involved in maturation and export of SDF-2. The exposure of the protease domain of tagC on the surface of the prestalk cells were it can convert acbA to SDF-2 is induced by GABA. Intercellular communication via tagC may mediate integration of cellular differentiation with morphogenesis. In the C-terminal section; belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. | 0.419 |
PufA | yakA | Q54WA7 | Q54QV3 | RNA binding protein. | Probable serine/threonine-protein kinase yakA; General sensor of environmental conditions, such as heat stress, effecting changes through pkaC. Essential for survival to nitrosoative and oxidative stresses. Required for cell cycle control, not only at the onset but also during development (aggregation process and postaggregative development). | 0.828 |
acbA | PufA | Q5FXM5 | Q54WA7 | Acyl-CoA-binding protein; Binds to acyl-CoA. Processed into the SDF-2 (spore differentiation factor 2) a peptide which triggers sporulation. SDF-2 appears to stimulate prestalk cells to release additional SDF-2 by acting through a signal transduction pathway that also involves dhkA, regA and PKA. Induces encapsulation of prespore cells in a dhkA- dependent manner. GABA induces the release of acbA from prespore cells and induces the exposure of tagC on the surface of prestalk cells where it can convert acbA to SDF-2. Glutamate acts as a competitive inhibitor and is also able to inhibit [...] | RNA binding protein. | 0.423 |
acbA | acgA | Q5FXM5 | Q03101 | Acyl-CoA-binding protein; Binds to acyl-CoA. Processed into the SDF-2 (spore differentiation factor 2) a peptide which triggers sporulation. SDF-2 appears to stimulate prestalk cells to release additional SDF-2 by acting through a signal transduction pathway that also involves dhkA, regA and PKA. Induces encapsulation of prespore cells in a dhkA- dependent manner. GABA induces the release of acbA from prespore cells and induces the exposure of tagC on the surface of prestalk cells where it can convert acbA to SDF-2. Glutamate acts as a competitive inhibitor and is also able to inhibit [...] | Adenylate cyclase, germination specific; Has a large extracellular domain which may be involved in the recognition of an extracellular signal present during germination, leading to activation or inhibition of cAMP synthesis by the cytoplasmic domain. | 0.481 |
acbA | dhkC | Q5FXM5 | Q95PI2 | Acyl-CoA-binding protein; Binds to acyl-CoA. Processed into the SDF-2 (spore differentiation factor 2) a peptide which triggers sporulation. SDF-2 appears to stimulate prestalk cells to release additional SDF-2 by acting through a signal transduction pathway that also involves dhkA, regA and PKA. Induces encapsulation of prespore cells in a dhkA- dependent manner. GABA induces the release of acbA from prespore cells and induces the exposure of tagC on the surface of prestalk cells where it can convert acbA to SDF-2. Glutamate acts as a competitive inhibitor and is also able to inhibit [...] | Hybrid signal transduction histidine kinase C; Acts in a signal transduction pathway that regulates the slug versus culmination choice. Believed to be the first component of a phosphorelay that couples the sensing of ammonia to the modulation of PKA activity and hence activates culmination and spore germination. Ammonium transporters amtA and amtC are thought to respectively activate and inhibit dhkC phosphorelay. This protein probably undergoes an ATP-dependent autophosphorylation at conserved His residue in the kinase core, and a phosphoryl group is then transferred to a conserved as [...] | 0.450 |
acbA | rdeA | Q5FXM5 | Q54RR8 | Acyl-CoA-binding protein; Binds to acyl-CoA. Processed into the SDF-2 (spore differentiation factor 2) a peptide which triggers sporulation. SDF-2 appears to stimulate prestalk cells to release additional SDF-2 by acting through a signal transduction pathway that also involves dhkA, regA and PKA. Induces encapsulation of prespore cells in a dhkA- dependent manner. GABA induces the release of acbA from prespore cells and induces the exposure of tagC on the surface of prestalk cells where it can convert acbA to SDF-2. Glutamate acts as a competitive inhibitor and is also able to inhibit [...] | Phosphorelay intermediate protein rdeA; Phosphorelay protein that supplies phosphate to regA or accepts phosphate from regA; depending on the relative concentration of the phosphodonor proteins. In vitro, acts as a substrate for cheA (bacterial kinase). Plays a role in the development. ypd1 (yeast) can complement rdeA defect. | 0.400 |
acbA | tagC | Q5FXM5 | Q23868 | Acyl-CoA-binding protein; Binds to acyl-CoA. Processed into the SDF-2 (spore differentiation factor 2) a peptide which triggers sporulation. SDF-2 appears to stimulate prestalk cells to release additional SDF-2 by acting through a signal transduction pathway that also involves dhkA, regA and PKA. Induces encapsulation of prespore cells in a dhkA- dependent manner. GABA induces the release of acbA from prespore cells and induces the exposure of tagC on the surface of prestalk cells where it can convert acbA to SDF-2. Glutamate acts as a competitive inhibitor and is also able to inhibit [...] | Serine protease/ABC transporter B family protein tagC; May be directly involved in maturation and export of SDF-2. The exposure of the protease domain of tagC on the surface of the prestalk cells were it can convert acbA to SDF-2 is induced by GABA. Intercellular communication via tagC may mediate integration of cellular differentiation with morphogenesis. In the C-terminal section; belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. | 0.815 |
acgA | PufA | Q03101 | Q54WA7 | Adenylate cyclase, germination specific; Has a large extracellular domain which may be involved in the recognition of an extracellular signal present during germination, leading to activation or inhibition of cAMP synthesis by the cytoplasmic domain. | RNA binding protein. | 0.524 |
acgA | acbA | Q03101 | Q5FXM5 | Adenylate cyclase, germination specific; Has a large extracellular domain which may be involved in the recognition of an extracellular signal present during germination, leading to activation or inhibition of cAMP synthesis by the cytoplasmic domain. | Acyl-CoA-binding protein; Binds to acyl-CoA. Processed into the SDF-2 (spore differentiation factor 2) a peptide which triggers sporulation. SDF-2 appears to stimulate prestalk cells to release additional SDF-2 by acting through a signal transduction pathway that also involves dhkA, regA and PKA. Induces encapsulation of prespore cells in a dhkA- dependent manner. GABA induces the release of acbA from prespore cells and induces the exposure of tagC on the surface of prestalk cells where it can convert acbA to SDF-2. Glutamate acts as a competitive inhibitor and is also able to inhibit [...] | 0.481 |
acgA | dhkC | Q03101 | Q95PI2 | Adenylate cyclase, germination specific; Has a large extracellular domain which may be involved in the recognition of an extracellular signal present during germination, leading to activation or inhibition of cAMP synthesis by the cytoplasmic domain. | Hybrid signal transduction histidine kinase C; Acts in a signal transduction pathway that regulates the slug versus culmination choice. Believed to be the first component of a phosphorelay that couples the sensing of ammonia to the modulation of PKA activity and hence activates culmination and spore germination. Ammonium transporters amtA and amtC are thought to respectively activate and inhibit dhkC phosphorelay. This protein probably undergoes an ATP-dependent autophosphorylation at conserved His residue in the kinase core, and a phosphoryl group is then transferred to a conserved as [...] | 0.510 |
acgA | pkaR | Q03101 | P05987 | Adenylate cyclase, germination specific; Has a large extracellular domain which may be involved in the recognition of an extracellular signal present during germination, leading to activation or inhibition of cAMP synthesis by the cytoplasmic domain. | cAMP-dependent protein kinase regulatory subunit. | 0.738 |
acgA | rdeA | Q03101 | Q54RR8 | Adenylate cyclase, germination specific; Has a large extracellular domain which may be involved in the recognition of an extracellular signal present during germination, leading to activation or inhibition of cAMP synthesis by the cytoplasmic domain. | Phosphorelay intermediate protein rdeA; Phosphorelay protein that supplies phosphate to regA or accepts phosphate from regA; depending on the relative concentration of the phosphodonor proteins. In vitro, acts as a substrate for cheA (bacterial kinase). Plays a role in the development. ypd1 (yeast) can complement rdeA defect. | 0.404 |
acgA | yakA | Q03101 | Q54QV3 | Adenylate cyclase, germination specific; Has a large extracellular domain which may be involved in the recognition of an extracellular signal present during germination, leading to activation or inhibition of cAMP synthesis by the cytoplasmic domain. | Probable serine/threonine-protein kinase yakA; General sensor of environmental conditions, such as heat stress, effecting changes through pkaC. Essential for survival to nitrosoative and oxidative stresses. Required for cell cycle control, not only at the onset but also during development (aggregation process and postaggregative development). | 0.402 |
amtA | dhkC | Q9BLG4 | Q95PI2 | Ammonium transporter 1; Ammonium transporter that mediates the excretion of ammonium. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development; Belongs to the ammonia transporter channel (TC 1.A.11.2) family. | Hybrid signal transduction histidine kinase C; Acts in a signal transduction pathway that regulates the slug versus culmination choice. Believed to be the first component of a phosphorelay that couples the sensing of ammonia to the modulation of PKA activity and hence activates culmination and spore germination. Ammonium transporters amtA and amtC are thought to respectively activate and inhibit dhkC phosphorelay. This protein probably undergoes an ATP-dependent autophosphorylation at conserved His residue in the kinase core, and a phosphoryl group is then transferred to a conserved as [...] | 0.455 |
amtC | dhkC | Q8MXY0 | Q95PI2 | Ammonium transporter 3; Ammonium transporter that mediates the import of ammonium in prespore cells. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development. May function as an ammonia sensor that relays information concerning ammonia concentrations to the signaling pathway involved in the slug versus culmination choice and regulates prestalk gene expression. | Hybrid signal transduction histidine kinase C; Acts in a signal transduction pathway that regulates the slug versus culmination choice. Believed to be the first component of a phosphorelay that couples the sensing of ammonia to the modulation of PKA activity and hence activates culmination and spore germination. Ammonium transporters amtA and amtC are thought to respectively activate and inhibit dhkC phosphorelay. This protein probably undergoes an ATP-dependent autophosphorylation at conserved His residue in the kinase core, and a phosphoryl group is then transferred to a conserved as [...] | 0.797 |
cytC | dhkC | Q869N1 | Q95PI2 | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | Hybrid signal transduction histidine kinase C; Acts in a signal transduction pathway that regulates the slug versus culmination choice. Believed to be the first component of a phosphorelay that couples the sensing of ammonia to the modulation of PKA activity and hence activates culmination and spore germination. Ammonium transporters amtA and amtC are thought to respectively activate and inhibit dhkC phosphorelay. This protein probably undergoes an ATP-dependent autophosphorylation at conserved His residue in the kinase core, and a phosphoryl group is then transferred to a conserved as [...] | 0.450 |