STRING 9.1 
  PHF21A protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PHF21A
PHD finger protein 21A; Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits AOF2/LSD1-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation (680 aa)
(Homo sapiens)
Predicted Functional Partners:
KDM1A
lysine (K)-specific demethylase 1A; Histone demethylase that demethylates 'Lys-4' of histone H3 [...] (852 aa)
     0.999
HDAC2
histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (582 aa)
     0.997
HDAC1
histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (482 aa)
     0.990
HMG20B
high-mobility group 20B; Required for correct progression through G2 phase of the cell cycle an [...] (317 aa)
     0.989
RCOR1
REST corepressor 1; Essential component of the BHC complex, a corepressor complex that represse [...] (482 aa)
     0.989
ING2
inhibitor of growth family, member 2; Seems to be involved in p53/TP53 activation and p53/TP53- [...] (280 aa)
      0.932
HDAC9
histone deacetylase 9; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (1069 aa)
      0.928
HDAC8
histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (377 aa)
      0.919
HDAC3
histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (428 aa)
      0.919
CHD4
chromodomain helicase DNA binding protein 4; Probable transcription regulator (1912 aa)
     0.914
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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