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  CDK4 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CDK4
Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3); Probably involved in the control of the cell cycle (303 aa)
(Homo sapiens)
Predicted Functional Partners:
CCND1
G1/S-specific cyclin-D1 (PRAD1 oncogene) (BCL-1 oncogene); Essential for the control of the cel [...] (295 aa)
    ••• 0.999
CDKN2A
Cyclin-dependent kinase inhibitor 2A, isoform 4 (p14ARF) (p19ARF); Capable of inducing cell cyc [...] (173 aa)
    ••• 0.999
CCND3
G1/S-specific cyclin-D3; Essential for the control of the cell cycle at the G1/S (start) transi [...] (292 aa)
    ••• 0.999
CCND2
G1/S-specific cyclin-D2; Essential for the control of the cell cycle at the G1/S (start) transi [...] (289 aa)
    ••• 0.999
CDKN1A
Cyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1) (Melanoma differentiation [...] (164 aa)
    ••• 0.999
CDKN1B
Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1); Importa [...] (198 aa)
    ••• 0.999
CDKN2B
Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b) (p15INK4B) (Multiple tumor suppre [...] (138 aa)
    ••• 0.999
PCNA
Proliferating cell nuclear antigen (PCNA) (Cyclin); This protein is an auxiliary protein of DNA [...] (261 aa)
    ••• 0.999
RB1
Retinoblastoma-associated protein (PP110) (P105-RB) (RB); Key regulator of entry into cell divi [...] (928 aa)
    ••• 0.999
CDC45L
CDC45-related protein (PORC-PI-1) (Cdc45); Required for initiation of chromosomal DNA replicati [...] (566 aa)
    • • 0.999
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.
Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:
additional (white) nodes         or: network depth
       
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