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ABCC11 ABCC11 ABCC12 ABCC12 ABCF2-2 ABCF2-2 ABCF2 ABCF2 ABCG4 ABCG4 MRPS7 MRPS7 SRARP SRARP ABCG8 ABCG8 ABCA10 ABCA10 ABCE1 ABCE1 ABCB1 ABCB1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ABCC11ATP-binding cassette sub-family C member 11; Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S- glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta- D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taur [...] (1382 aa)    
Predicted Functional Partners:
ABCC12
Multidrug resistance-associated protein 9; Probable transporter.
  
 
0.663
ABCF2-2
ATP binding cassette subfamily F member 2.
  
 
 0.567
ABCF2
ATP binding cassette subfamily F member 2.
  
 
 0.566
ABCG4
ATP-binding cassette sub-family G member 4; May be involved in macrophage lipid homeostasis.
   
 
 0.528
MRPS7
Mitochondrial ribosomal protein S7.
      
 0.519
SRARP
Steroid receptor-associated and regulated protein; May regulate the transcriptional function of androgen and estrogen receptors.
   
  
 0.500
ABCG8
ATP-binding cassette sub-family G member 8; ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG5 has ATPase activity.
   
 
 0.492
ABCA10
ATP-binding cassette sub-family A member 10; Probable transporter which may play a role in macrophage lipid homeostasis.
   
 
 0.487
ABCE1
ATP-binding cassette sub-family E member 1; Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'- linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly; Belongs to the ABC transporter superfamily. ABCE family.
      
 0.477
ABCB1
ATP-dependent translocase ABCB1; Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
   
 
0.476
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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