EGLN2 protein (Homo sapiens) - STRING network view

STRING 9.05

EGLN2 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	EGLN2	egl nine homolog 2 (C. elegans); Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation (407 aa)
		(Homo sapiens)
Predicted Functional Partners:
	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functi [...] (826 aa)	•	•	•		0.998
	VHL	von Hippel-Lindau tumor suppressor; Involved in the ubiquitination and subsequent proteasomal d [...] (213 aa)	•	•	•		0.981
	EPAS1	endothelial PAS domain protein 1; Transcription factor involved in the induction of oxygen regu [...] (870 aa)	•	•	•		0.966
	HIF3A	hypoxia inducible factor 3, alpha subunit; Involved in adaptive response to hypoxia. Suppresses [...] (669 aa)	•	•	•		0.964
	EGLN3	egl nine homolog 3 (C. elegans); Catalyzes the post-translational formation of 4- hydroxyprolin [...] (239 aa)	•	•	•	•	0.961
	TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); SIII, also known as [...] (112 aa)		•	•		0.936
	TCEB2	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B); SIII, also known as [...] (161 aa)		•	•		0.929
	CUL2	cullin 2; Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) [...] (745 aa)		•	•		0.921
	OS9	osteosarcoma amplified 9, endoplasmic reticulum lectin; Lectin which functions in endoplasmic r [...] (667 aa)		•	•		0.921
	RBX1	ring-box 1; Component of the SCF (SKP1-CUL1-F-box protein) and the CBC(VHL) (CUL2-elonging BC-V [...] (108 aa)		•	•		0.914

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Co-expression Experiments Databases Textmining

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