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This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
BBC3
Bcl-2-binding component 3 (p53 up-regulated modulator of apoptosis) (JFY-1); Essential mediator of p53-dependent and p53-independent apoptosis (193 aa)
(Homo sapiens)
Predicted Functional Partners:
BCL2
Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-d [...] (239 aa)
    ••• 0.999
BCL2L1
Apoptosis regulator Bcl-X (Bcl-2-like 1 protein); Potent inhibitor of cell death. Isoform Bcl-X [...] (233 aa)
    ••• 0.999
BAX
Apoptosis regulator BAX, membrane isoform alpha; Accelerates programmed cell death by binding t [...] (218 aa)
    • • 0.996
MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2- related protein EAT/mcl1) ( [...] (350 aa)
    • • 0.993
TP53
Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13); Acts [...] (393 aa)
      • 0.992
BAK1
Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2- like 7 protein); In the pr [...] (215 aa)
      • 0.991
CYCS
Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can ac [...] (105 aa)
      • 0.960
MDM2
Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Do [...] (491 aa)
      • 0.958
FOXO3A
Forkhead box protein O3A (Forkhead in rhabdomyosarcoma-like 1) (AF6q21 protein); Transcriptiona [...] (673 aa)
      • 0.951
BCL2L11
Bcl-2-like protein 11 (Bcl2-interacting mediator of cell death); Induces apoptosis. Isoform Bim [...] (198 aa)
      • 0.950
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.
Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:
additional (white) nodes         or: network depth