| Homo sapiens | MRD5 - Ras GTPase-activating protein SynGAP (Synaptic Ras GTPase-activating protein 1)(Synaptic Ras-GAP 1)(Neuronal RasGAP); Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR- mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By simi [...] |
