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MRD5 - Ras GTPase-activating protein SynGAP (Synaptic Ras GTPase-activating protein 1)(Synaptic Ras-GAP 1)(Neuronal RasGAP); Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR- mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By simi [...]
SYNGAP1 - synaptic Ras GTPase activating protein 1 homolog (rat)