IL12RB2 protein (Homo sapiens) - STRING network view

STRING 9.05

IL12RB2 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	IL12RB2	interleukin 12 receptor, beta 2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production (862 aa)
		(Homo sapiens)
Predicted Functional Partners:
	STAT4	signal transducer and activator of transcription 4; Carries out a dual function- signal transdu [...] (748 aa)	•	•	•	0.993
	IL12RB1	interleukin 12 receptor, beta 1; Functions as an interleukin receptor which binds interleukin-1 [...] (381 aa)	•	•	•	0.988
	IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation fact [...] (328 aa)	•	•	•	0.979
	IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation fact [...] (253 aa)	•	•	•	0.968
	JAK2	Janus kinase 2; Plays a role in leptin signaling and control of body weight (By similarity). Ty [...] (1132 aa)	•	•	•	0.968
	TYK2	tyrosine kinase 2; Probably involved in intracellular signal transduction by being involved in [...] (1187 aa)	•	•	•	0.968
	TBX21	T-box 21; Transcription factor that controls the expression of the TH1 cytokine, interferon-gam [...] (535 aa)		•	•	0.959
	IFNG	interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamm [...] (166 aa)		•	•	0.942
	SOCS3	suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feed [...] (225 aa)	•	•	•	0.941
	STAT1	signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of t [...] (750 aa)		•	•	0.938

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Co-expression Experiments Databases Textmining

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