Pik3r1 protein (Mus musculus) - STRING interaction network

Pik3r1 protein (Mus musculus) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues (724 aa)
		(Mus musculus)
Predicted Functional Partners:
	Irs1	insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. [...] (1231 aa)	•	•	•	0.999
	Irs2	insulin receptor substrate 2; May mediate the control of various cellular processes by insulin (1321 aa)	•	•	•	0.999
	Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; Phosphorylates PtdIns, PtdIns4P an [...] (1070 aa)	•	•	•	0.999
	Pdgfrb	platelet derived growth factor receptor, beta polypeptide; Receptor that binds specifically to [...] (1099 aa)	•	•	•	0.996
	Gab1	growth factor receptor bound protein 2-associated protein 1; Probably involved in EGF and insul [...] (695 aa)	•	•	•	0.996
	Rhog	ras homolog gene family, member G; Required for the formation of membrane ruffles during macrop [...] (191 aa)		•	•	0.984
	Akt1	thymoma viral proto-oncogene 1; General protein kinase capable of phosphorylating several known [...] (480 aa)		•	•	0.984
	Pik3cb	phosphatidylinositol 3-kinase, catalytic, beta polypeptide; Phosphorylates PtdIns, PtdIns4P and [...] (1064 aa)	•	•	•	0.983
	Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide (1045 aa)	•	•	•	0.979
	Pten	phosphatase and tensin homolog; Potential tumor suppressor. Acts as a phosphoinositide 3-phosph [...] (403 aa)		•	•	0.978

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Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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