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proV proV proZ proZ proW proW proX proX lpqZ lpqZ Rv3755c Rv3755c Rv3760 Rv3760 drrA drrA accD1 accD1 cobL cobL sirA sirA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
proVRv3758c, (MTV025.106c), len: 376 aa. Possible proV,osmoprotectant transport ATP-binding protein ABC transporter (see citation below), highly similar to osmoprotection proteins (proV) involved in glycine betaine/L-proline/choline transport, e.g. BAB58610|Q99RI3|OPUCA|SA2237|SAV2448 glycine betaine/carnitine/choline ABC transporter (ATP-binding) from Staphylococcus aureus (410 aa), FASTA scores: opt: 816, E(): 8.4e-39, (39.5% identity in 362 aa overlap); O34992|OPCA_BACSU|OPUCA glycine betaine/carnitine/choline transport ATP-binding protein from Bacillus subtilis (380 aa), FASTA scores: [...] (376 aa)    
Predicted Functional Partners:
proZ
Rv3756c, (MTV025.104c), len: 239 aa. Possible proZ,osmoprotectant transport integral membrane protein ABC transporter (see citation below), similar to osmoprotection proteins (proW, proZ) involved in glycine betaine/L-proline/choline transport, e.g. BAB58609|Q99RI4|OPUCB|SA2236|SAV2447 OPUCB protein (probable glycine betaine/carnitine/choline ABC transporter) from Staphylococcus aureus (211 aa) FASTA scores: opt: 434, E(): 2.5e-18, (36.6% identity in 194 aa overlap); Q45461|OPBB_BACSU|OPUBB|prow choline transport system permease protein (mediate the uptake of choline for synthesis of t [...]
 
 0.999
proW
Rv3757c, (MTV025.105c), len: 229 aa. Possible proW,osmoprotectant transport integral membrane protein ABC transporter (see citation below), similar to osmoprotection proteins (proW, proZ) involved in glycine betaine/L-proline/choline transport, e.g. BAB58607|Q99RI6|OPUCD|SA2234|SAV2445 OPUCD protein (probable glycine betaine/carnitine/choline ABC transporter) from Staphylococcus aureus (231 aa) FASTA scores: opt: 364, E(): 7.1e-15, (30.0% identity in 220 aa overlap); Q45461|OPBB_BACSU|OPUBB|prow choline transport system permease protein (mediate the uptake of choline for synthesis of t [...]
 
 0.999
proX
Rv3759c, (MTV025.107c), len: 315 aa. Possible proX,osmoprotectant-binding lipoprotein component of osmoprotectant transport system (see citation below),similar to osmoprotection proteins (proX) involved in glycine betaine/L-proline/choline transport, e.g. AAK79442|CAC1474 proline/glycine betaine ABC transport system periplasmic component from Clostridium acetobutylicum (303 aa), FASTA scores: opt: 308, E(): 1.2e-11, (27.4% identity in 314 aa overlap); Q9X4J2|PROXL|SCE19A.33 PROXL protein from Streptomyces coelicolor (322 aa), FASTA scores: opt: 302, E(): 3e-11,(27.2% identity in 327 aa [...]
 
 0.999
lpqZ
Probable lipoprotein LpqZ; Rv1244, (MTV006.16), len: 286 aa. Probable lipoprotein lpqZ, equivalent toU15180|MLU1518042 protein u1756x from Mycobacterium leprae (228 aa), FASTA scores: opt: 1039, E(): 0, (72.5% identity in 229 aa overlap). Similar to Mycobacterium tuberculosis hypothetical protein Rv3759c. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
 
 
 0.902
Rv3755c
Conserved protein; Rv3755c, (MTV025.103c), len: 199 aa. Conserved protein showing similarity to CAC47343|SMC03980 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (196 aa) FASTA scores: opt: 244, E(): 4.1e-09,(30.9% identity in 191 aa overlap); Q9I2B5|PA1994 from Pseudomonas aeruginosa (187 aa), FASTA scores: opt: 226,E(): 6e-08, (29.9% identity in 194 aa overlap); and Q98N73|MLR0268 hypothetical protein (183 aa), FASTA scores: opt: 234, E(): 1.8e-08, (27.05% identity in 185 aa overlap).
  
    0.888
Rv3760
Rv3760, (MTV025.108), len: 100 aa. Possible conserved membrane protein, equivalent to Q50094|ML2366|MLCB12.11c putative membrane protein from Mycobacterium leprae (113 aa), FASTA scores: opt: 423, E(): 1.2e-20, (67.7% identity in 99 aa overlap). Also similar with Q9JST1|NMA2149 putative inner membrane hypothetical protein from Neisseria meningitidis (serogroup A) (104 aa),FASTA scores: opt: 113, E(): 0.95, (33.85% identity in 62 aa overlap); and showing similarity with Q9ZAX7 ABC transporter membrane protein subunit from Streptococcus mutans (498 aa), FASTA scores: opt: 108, E(): 6.7, [...]
  
    0.775
drrA
Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA; Part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP; Belongs to the ABC transporter superfamily. Drug exporter-1 (DrugE1) (TC 3.A.1.105) family.
 
   
0.678
accD1
Rv2502c, (MTCY07A7.08c), len: 529 aa. Probable accD1, acetyl-/propionyl-CoA carboxylase (beta subunit), similar, but with N-terminus shorter, to Q9L077|ACCD1 from Streptomyces coelicolor (538 aa), FASTA scores: opt: 2747,E(): 1.9e-159, (77.9% identity in 516 aa overlap). Also similar to others e.g. AAK24141|CC2170 from Caulobacter crescentus (530 aa), FASTA scores: opt: 2413, E(): 3.8e-139, (69.4% identity in 529 aa overlap); BAB54131|MLL7731 from Rhizobium loti (537 aa), FASTA scores: opt: 2399, E(): 2.7e-138, (67.4% identity in 527 aa overlap); etc. Could belong to the ACCD/PCCB family.
  
  
 0.663
cobL
Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL; Catalyzes the methylation of both C-5 and C-15 in precorrin- 6Y to form precorrin-8X.
  
  
 0.658
sirA
Ferredoxin-dependent sulfite reductase SirA; Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
   
  
 0.530
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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