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This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
Pik3cg
phosphoinositide-3-kinase, catalytic, gamma polypeptide; 3-phosphorylates the cellular phosphoinositide PtdIns- 4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5- triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production (1112 aa)
(Mus musculus)
Predicted Functional Partners:
Akt1
thymoma viral proto-oncogene 1; General protein kinase capable of phosphorylating several known [...] (480 aa)
     •• 0.995
Pten
phosphatase and tensin homolog; Potential tumor suppressor. Acts as a phosphoinositide 3-phosph [...] (403 aa)
     •• 0.987
Pik3r6
expressed sequence BB220380; Regulatory subunit of the PI3K gamma complex. Acts as an adapter t [...] (756 aa)
    • • 0.982
Pik3r5
phosphoinositide-3-kinase, regulatory subunit 5, p101; Regulatory subunit of the PI3K gamma com [...] (871 aa)
    ••• 0.981
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); Binds to activate [...] (724 aa)
     •• 0.975
Map2k1
mitogen activated protein kinase kinase 1; Catalyzes the concomitant phosphorylation of a threo [...] (393 aa)
     •• 0.948
Mapk1
mitogen activated protein kinase 1; Involved in both the initiation and regulation of meiosis, [...] (358 aa)
     •• 0.944
Pdpk1
3-phosphoinositide dependent protein kinase-1; Phosphorylates and activates not only PKB/AKT, b [...] (559 aa)
     •• 0.942
Irs1
insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. [...] (1231 aa)
     •• 0.929
Grb2
growth factor receptor bound protein 2; Adapter protein that provides a critical link between c [...] (217 aa)
    ••• 0.928
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.
Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:
additional (white) nodes         or: network depth