node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Eid3 | Maged2 | ENSMUSP00000147261 | ENSMUSP00000026302 | EP300-interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double- strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity); Belongs to the NSE4 family. | Melanoma antigen, family D, 2. | 0.493 |
Eid3 | Nsmce1 | ENSMUSP00000147261 | ENSMUSP00000033006 | EP300-interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double- strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity); Belongs to the NSE4 family. | Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE [...] | 0.968 |
Eid3 | Nsmce4a | ENSMUSP00000147261 | ENSMUSP00000125300 | EP300-interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double- strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity); Belongs to the NSE4 family. | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | 0.733 |
Eid3 | Smc5 | ENSMUSP00000147261 | ENSMUSP00000153364 | EP300-interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double- strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity); Belongs to the NSE4 family. | Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 (By similarity). | 0.975 |
Eid3 | Smc6 | ENSMUSP00000147261 | ENSMUSP00000020931 | EP300-interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double- strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity); Belongs to the NSE4 family. | Structural maintenance of chromosomes protein 6; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). | 0.982 |
Maged2 | Eid3 | ENSMUSP00000026302 | ENSMUSP00000147261 | Melanoma antigen, family D, 2. | EP300-interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double- strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity); Belongs to the NSE4 family. | 0.493 |
Maged2 | Nap1l1 | ENSMUSP00000026302 | ENSMUSP00000151972 | Melanoma antigen, family D, 2. | Nucleosome assembly protein 1-like 1; Plays a key role in the regulation of embryonic neurogenesis. Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development. Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter. Belongs to the nucleosome assembly protein (NAP) family. | 0.601 |
Maged2 | Nap1l4 | ENSMUSP00000026302 | ENSMUSP00000146474 | Melanoma antigen, family D, 2. | Nucleosome assembly protein 1-like 4; Acts as histone chaperone in nucleosome assembly. In condensing spermatids, mediates the loading of the heterodimer composed of histones H2AB1 and H2BC1/TH2B onto the nucleosomes, thereby promoting the replacement of histones to protamine in male germ cells. | 0.584 |
Maged2 | Nap1l5 | ENSMUSP00000026302 | ENSMUSP00000062780 | Melanoma antigen, family D, 2. | Nucleosome assembly protein 1-like 5. | 0.554 |
Maged2 | Nsmce1 | ENSMUSP00000026302 | ENSMUSP00000033006 | Melanoma antigen, family D, 2. | Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE [...] | 0.596 |
Maged2 | Nsmce4a | ENSMUSP00000026302 | ENSMUSP00000125300 | Melanoma antigen, family D, 2. | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | 0.493 |
Maged2 | Slit3 | ENSMUSP00000026302 | ENSMUSP00000066857 | Melanoma antigen, family D, 2. | Slit homolog 3 protein; May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors. | 0.505 |
Maged2 | Smc5 | ENSMUSP00000026302 | ENSMUSP00000153364 | Melanoma antigen, family D, 2. | Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 (By similarity). | 0.539 |
Maged2 | Smc6 | ENSMUSP00000026302 | ENSMUSP00000020931 | Melanoma antigen, family D, 2. | Structural maintenance of chromosomes protein 6; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). | 0.500 |
Maged2 | Trp53 | ENSMUSP00000026302 | ENSMUSP00000104298 | Melanoma antigen, family D, 2. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.561 |
Nap1l1 | Maged2 | ENSMUSP00000151972 | ENSMUSP00000026302 | Nucleosome assembly protein 1-like 1; Plays a key role in the regulation of embryonic neurogenesis. Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development. Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter. Belongs to the nucleosome assembly protein (NAP) family. | Melanoma antigen, family D, 2. | 0.601 |
Nap1l1 | Nap1l4 | ENSMUSP00000151972 | ENSMUSP00000146474 | Nucleosome assembly protein 1-like 1; Plays a key role in the regulation of embryonic neurogenesis. Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development. Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter. Belongs to the nucleosome assembly protein (NAP) family. | Nucleosome assembly protein 1-like 4; Acts as histone chaperone in nucleosome assembly. In condensing spermatids, mediates the loading of the heterodimer composed of histones H2AB1 and H2BC1/TH2B onto the nucleosomes, thereby promoting the replacement of histones to protamine in male germ cells. | 0.650 |
Nap1l1 | Nap1l5 | ENSMUSP00000151972 | ENSMUSP00000062780 | Nucleosome assembly protein 1-like 1; Plays a key role in the regulation of embryonic neurogenesis. Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development. Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter. Belongs to the nucleosome assembly protein (NAP) family. | Nucleosome assembly protein 1-like 5. | 0.582 |
Nap1l4 | Maged2 | ENSMUSP00000146474 | ENSMUSP00000026302 | Nucleosome assembly protein 1-like 4; Acts as histone chaperone in nucleosome assembly. In condensing spermatids, mediates the loading of the heterodimer composed of histones H2AB1 and H2BC1/TH2B onto the nucleosomes, thereby promoting the replacement of histones to protamine in male germ cells. | Melanoma antigen, family D, 2. | 0.584 |
Nap1l4 | Nap1l1 | ENSMUSP00000146474 | ENSMUSP00000151972 | Nucleosome assembly protein 1-like 4; Acts as histone chaperone in nucleosome assembly. In condensing spermatids, mediates the loading of the heterodimer composed of histones H2AB1 and H2BC1/TH2B onto the nucleosomes, thereby promoting the replacement of histones to protamine in male germ cells. | Nucleosome assembly protein 1-like 1; Plays a key role in the regulation of embryonic neurogenesis. Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development. Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter. Belongs to the nucleosome assembly protein (NAP) family. | 0.650 |