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pycard pycard caspa caspa caspbl caspbl caspb caspb casp8 casp8 casp22 casp22 nlrp1 nlrp1 F1QGE7_DANRE F1QGE7_DANRE LOC103910107 LOC103910107 il1b il1b caiap caiap
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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pycardApoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa- dependent apoptosis. In innate immune response acts as an integral adapter in the assembly of NLRP1 inflammasomes which activate caspases caspa and caspb leading to processing and secretion of the proinflammatory cytokine il1b. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Also involved [...] (203 aa)    
Predicted Functional Partners:
caspa
Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...]
   
0.997
caspbl
Caspase b,-like; Belongs to the peptidase C14A family.
   
 0.993
caspb
Caspase b subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form following the recruitment of caspase caspa. Its subsequent activation causes the cleavage of the midformed pro-il1b and results in il1b maturation and secretion in the extracellular milieu. [...]
   
 0.965
casp8
Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
   
 0.963
casp22
Caspase 22, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
   
 0.942
nlrp1
NACHT, LRR and PYD domains-containing protein 1 homolog; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, which activates caspases caspa and caspb leading to processing and secretion of proinflammatory cytokines. Required for the sequential recruitment of pro-caspa and pro-caspb to the inflammasome, which promotes activation of the caspases and the caspa/b-catalyzed il1b maturation and secretion in the e [...]
   
0.937
F1QGE7_DANRE
Si:ch211-196h16.4.
    
 0.934
LOC103910107
NACHT domain-containing protein.
   
 0.917
il1b
Interleukin-1.
   
 
 0.902
caiap
CARD- and ANK-domain containing inflammasome adapter protein; Probable inflammasome component which mediates inflammasome- dependent resistance to bacterial infection by S.typhimurium through association with activated caspa.
    
 
 0.748
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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