Tp53 protein (Mus musculus) - STRING interaction network

Tp53 protein (Mus musculus) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	Tp53	transformation related protein 53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) (378 aa)
		(Mus musculus)
Predicted Functional Partners:
	Mdm2	transformed mouse 3T3 cell double minute 2; Inhibits TP53/p53- and TP73/p73-mediated cell cycle [...] (489 aa)	•	•	•	0.999
	Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21); May be the important intermediate by which p53 medi [...] (159 aa)	•	•	•	0.999
	Cdkn2a	cyclin-dependent kinase inhibitor 2A; Capable of inducing cell cycle arrest in G1 and G2 phases [...] (169 aa)	•	•	•	0.999
	Atm	ataxia telangiectasia mutated homolog (human); Serine/threonine protein kinase which activates [...] (3068 aa)	•	•	•	0.998
	ENSMUSG00000022521	CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation [...] (2442 aa)	•	•	•	0.998
	Chek2	CHK2 checkpoint homolog (S. pombe); Regulates cell cycle checkpoints and apoptosis in response [...] (546 aa)	•	•	•	0.998
	E2f1	E2F transcription factor 1; Transcription activator that binds DNA cooperatively with dp protei [...] (432 aa)	•		•	0.997
	Prkdc	protein kinase, DNA activated, catalytic polypeptide; Serine/threonine-protein kinase that acts [...] (4128 aa)	•	•	•	0.996
	Mdm4	transformed mouse 3T3 cell double minute 4; Inhibits p53- and p73-mediated cell cycle arrest an [...] (490 aa)	•	•	•	0.995
	Brca1	breast cancer 1; Plays a central role in DNA repair by facilitating cellular response to DNA re [...] (1812 aa)	•	•	•	0.995

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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