STRINGSTRING
LECRK19 LECRK19 RBOHD RBOHD T5E8.190 T5E8.190 NSH3 NSH3 APY2 APY2 HMGB2 HMGB2 F9K23.5 F9K23.5 APY1 APY1 LYM3 LYM3 WAK1 WAK1 HMGB1 HMGB1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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LECRK19L-type lectin-domain containing receptor kinase I.9; Essential receptor for extracellular ATP. Binds ATP with high affinity through its extracellular legume-lectin like region. Is required for ATP-induced intracellular calcium response, mitogen-activated protein kinase 3 (MPK3) and MPK6 activation and ATP-induced gene expression. May play a variety of roles in stress resistance. May be involved in protein-protein interactions with RGD motif-containing proteins as potential ligands. Plays probably a structural and signaling role at the plant cell surfaces. (766 aa)    
Predicted Functional Partners:
RBOHD
Respiratory burst oxidase homolog protein D; Calcium-dependent NADPH oxidase that generates superoxide. Involved in the generation of reactive oxygen species (ROS) during incompatible interactions with pathogens and in UV-B and abscisic acid ROS-dependent signaling. Might be required for ROS signal amplification during light stress. Belongs to the RBOH (TC 5.B.1.3) family.
   
  
 0.841
T5E8.190
CD2-binding protein-like protein.
      
 0.785
NSH3
Inosine-uridine preferring nucleoside hydrolase family protein.
   
  
 0.784
APY2
Apyrase 2; Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Substrate preference is ATP > ADP. Functions with APY1 to reduce extracellular ATP level which is essential for pollen germination and normal plant development. Plays a role in the regulation of stomatal function by modulating extracellular ATP levels in guard cells; Belongs to the GDA1/CD39 NTPase family.
      
 0.757
HMGB2
High mobility group B protein 2; Binds preferentially double-stranded DNA. Confers sensitivity to salt and drought stresses.
    
 
 0.727
F9K23.5
At1g58420.
      
 0.718
APY1
Apyrase 1; Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Substrate preference is ATP > ADP. Functions with APY2 to reduce extracellular ATP level which is essential for pollen germination and normal plant development. Plays a role in the regulation of stomatal function by modulating extracellular ATP levels in guard cells. Belongs to the GDA1/CD39 NTPase family.
      
 0.717
LYM3
LysM domain-containing GPI-anchored protein 3; Required as a cell surface receptor for peptidoglycan (PGN) elicitor signaling leading to innate immunity. Plays an essential role in detecting PGNs and restricting bacterial growth (of Pseudomonas syringae pv. tomato DC3000 for example).
      
 0.653
WAK1
Wall-associated receptor kinase 1; Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development. Required during plant's response to pathogen infection and in plant defense against heavy metal toxicity. Phosphorylates the oxygen-evolving enhancer protein 2 (OEE2) in an GRP-3-dependent manner.
  
   
0.643
HMGB1
High mobility group B protein 1; Binds preferentially double-stranded DNA. Modulates general plant growth and stress tolerance. Confers sensitivity to salt and genotoxic (methyl methanesulfonate, MMS) stresses. Belongs to the HMGB family.
    
 
 0.640
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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