node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IL12B | IL12RB1 | ENSSSCP00000045805 | ENSSSCP00000061372 | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | Interleukin 12 receptor subunit beta 1. | 0.991 |
IL12B | IL12RB2 | ENSSSCP00000045805 | ENSSSCP00000004110 | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | Interleukin-12 receptor subunit beta-2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway; Belongs to the type I cytokine receptor family. Type 2 subfamily. | 0.940 |
IL12B | IL13RA1 | ENSSSCP00000045805 | ENSSSCP00000013433 | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | Uncharacterized protein. | 0.652 |
IL12B | IL20RA | ENSSSCP00000045805 | ENSSSCP00000059834 | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | Interleukin 20 receptor subunit alpha. | 0.650 |
IL12B | IL22RA1 | ENSSSCP00000045805 | ENSSSCP00000047621 | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | Interleukin 22 receptor subunit alpha 1. | 0.650 |
IL12B | IL23A | ENSSSCP00000045805 | ENSSSCP00000039363 | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | Interleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] | 0.994 |
IL12B | IL23R | ENSSSCP00000045805 | ENSSSCP00000071641 | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | Interleukin 23 receptor. | 0.935 |
IL12B | IL4R | ENSSSCP00000045805 | ENSSSCP00000008346 | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). | 0.698 |
IL12B | JAK2 | ENSSSCP00000045805 | ENSSSCP00000029236 | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.584 |
IL12B | P4HB | ENSSSCP00000045805 | ENSSSCP00000068719 | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | Protein disulfide-isomerase. | 0.770 |
IL12RB1 | IL12B | ENSSSCP00000061372 | ENSSSCP00000045805 | Interleukin 12 receptor subunit beta 1. | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | 0.991 |
IL12RB1 | IL12RB2 | ENSSSCP00000061372 | ENSSSCP00000004110 | Interleukin 12 receptor subunit beta 1. | Interleukin-12 receptor subunit beta-2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway; Belongs to the type I cytokine receptor family. Type 2 subfamily. | 0.971 |
IL12RB1 | IL23A | ENSSSCP00000061372 | ENSSSCP00000039363 | Interleukin 12 receptor subunit beta 1. | Interleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] | 0.973 |
IL12RB1 | IL23R | ENSSSCP00000061372 | ENSSSCP00000071641 | Interleukin 12 receptor subunit beta 1. | Interleukin 23 receptor. | 0.987 |
IL12RB1 | JAK2 | ENSSSCP00000061372 | ENSSSCP00000029236 | Interleukin 12 receptor subunit beta 1. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.951 |
IL12RB2 | IL12B | ENSSSCP00000004110 | ENSSSCP00000045805 | Interleukin-12 receptor subunit beta-2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway; Belongs to the type I cytokine receptor family. Type 2 subfamily. | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | 0.940 |
IL12RB2 | IL12RB1 | ENSSSCP00000004110 | ENSSSCP00000061372 | Interleukin-12 receptor subunit beta-2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway; Belongs to the type I cytokine receptor family. Type 2 subfamily. | Interleukin 12 receptor subunit beta 1. | 0.971 |
IL12RB2 | IL23A | ENSSSCP00000004110 | ENSSSCP00000039363 | Interleukin-12 receptor subunit beta-2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway; Belongs to the type I cytokine receptor family. Type 2 subfamily. | Interleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] | 0.750 |
IL12RB2 | JAK2 | ENSSSCP00000004110 | ENSSSCP00000029236 | Interleukin-12 receptor subunit beta-2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway; Belongs to the type I cytokine receptor family. Type 2 subfamily. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.949 |
IL13RA1 | IL12B | ENSSSCP00000013433 | ENSSSCP00000045805 | Uncharacterized protein. | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | 0.652 |