SOCS1 protein (Homo sapiens) - STRING interaction network

SOCS1 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	SOCS1	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3); SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates [...] (211 aa)
		(Homo sapiens)
Predicted Functional Partners:
	JAK2	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2); Plays a role in leptin sig [...] (1132 aa)	•	•	•	0.999
	JAK1	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1); Tyrosine kinase of the non [...] (1156 aa)	•	•	•	0.998
	IFNGR1	Interferon-gamma receptor alpha chain precursor (IFN-gamma-R1) (CD119 antigen) (CDw119); Recept [...] (489 aa)	•	•	•	0.997
	INSR	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains- Insulin receptor subun [...] (1382 aa)	•	•	•	0.996
	STAT6	Signal transducer and activator of transcription 6 (IL-4 Stat); Carries out a dual function- si [...] (847 aa)		•	•	0.996
	STAT5B	Signal transducer and activator of transcription 5B; Carries out a dual function- signal transd [...] (787 aa)		•	•	0.993
	IRS1	Insulin receptor substrate 1 (IRS-1); May mediate the control of various cellular processes by [...] (1242 aa)	•	•	•	0.993
	IRS2	Insulin receptor substrate 2 (IRS-2); May mediate the control of various cellular processes by [...] (1338 aa)	•	•	•	0.993
	STAT1	Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 comp [...] (750 aa)		•	•	0.993
	TRIM8	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING fin [...] (553 aa)	•		•	0.993

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Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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