node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP30 | GIMAP4 | ENSP00000356992 | ENSP00000419545 | Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | 0.540 |
FGL2 | GIMAP4 | ENSP00000248598 | ENSP00000419545 | Fibroleukin; May play a role in physiologic lymphocyte functions at mucosal sites. | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | 0.606 |
FGL2 | GIMAP6 | ENSP00000248598 | ENSP00000479580 | Fibroleukin; May play a role in physiologic lymphocyte functions at mucosal sites. | GTPase, IMAP family member 6. | 0.428 |
FGL2 | GIMAP8 | ENSP00000248598 | ENSP00000305107 | Fibroleukin; May play a role in physiologic lymphocyte functions at mucosal sites. | GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. | 0.456 |
FGL2 | GZMA | ENSP00000248598 | ENSP00000274306 | Fibroleukin; May play a role in physiologic lymphocyte functions at mucosal sites. | Granzyme A; Abundant protease in the cytosolic granules of cytotoxic T- cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. Belongs to the peptidase S1 family. Granzym [...] | 0.474 |
GIMAP1 | GIMAP4 | ENSP00000302833 | ENSP00000419545 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | 0.818 |
GIMAP1 | GIMAP5 | ENSP00000302833 | ENSP00000351473 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the [...] | 0.710 |
GIMAP1 | GIMAP6 | ENSP00000302833 | ENSP00000479580 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | GTPase, IMAP family member 6. | 0.827 |
GIMAP1 | GIMAP7 | ENSP00000302833 | ENSP00000315474 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | GTPase IMAP family member 7; The dimer has GTPase activity; the active site contains residues from both subunits. | 0.833 |
GIMAP1 | GIMAP8 | ENSP00000302833 | ENSP00000305107 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. | 0.893 |
GIMAP1-GIMAP5 | GIMAP4 | ENSP00000477920 | ENSP00000419545 | GIMAP1-GIMAP5 readthrough. | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | 0.525 |
GIMAP1-GIMAP5 | GIMAP5 | ENSP00000477920 | ENSP00000351473 | GIMAP1-GIMAP5 readthrough. | GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the [...] | 0.802 |
GIMAP1-GIMAP5 | GIMAP6 | ENSP00000477920 | ENSP00000479580 | GIMAP1-GIMAP5 readthrough. | GTPase, IMAP family member 6. | 0.749 |
GIMAP1-GIMAP5 | GIMAP7 | ENSP00000477920 | ENSP00000315474 | GIMAP1-GIMAP5 readthrough. | GTPase IMAP family member 7; The dimer has GTPase activity; the active site contains residues from both subunits. | 0.576 |
GIMAP1-GIMAP5 | GIMAP8 | ENSP00000477920 | ENSP00000305107 | GIMAP1-GIMAP5 readthrough. | GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. | 0.612 |
GIMAP4 | ARHGAP30 | ENSP00000419545 | ENSP00000356992 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. | 0.540 |
GIMAP4 | FGL2 | ENSP00000419545 | ENSP00000248598 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | Fibroleukin; May play a role in physiologic lymphocyte functions at mucosal sites. | 0.606 |
GIMAP4 | GIMAP1 | ENSP00000419545 | ENSP00000302833 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | 0.818 |
GIMAP4 | GIMAP1-GIMAP5 | ENSP00000419545 | ENSP00000477920 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | GIMAP1-GIMAP5 readthrough. | 0.525 |
GIMAP4 | GIMAP5 | ENSP00000419545 | ENSP00000351473 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the [...] | 0.898 |