Socs2 protein (Rattus norvegicus) - STRING interaction network

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Your Input:
	Socs2	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2); SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (198 aa)
		(Rattus norvegicus)
Predicted Functional Partners:
	Ghr	Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains- Growth hormo [...] (639 aa)	•	•	•		0.983
	Jak2	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2); Tyrosine kinase of the non [...] (1132 aa)		•	•		0.953
	ENSRNOG00000017727	prolactin receptor (613 aa)	•	•	•		0.906
	Epor	Erythropoietin receptor precursor (EPO-R); Receptor for erythropoietin. Mediates erythropoietin [...] (507 aa)	•	•	•		0.878
	Socs3	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3); SOCS family pro [...] (225 aa)	•	•	•	•	0.873
	Stat5a	Signal transducer and activator of transcription 5A (Mammary gland factor); Carries out a dual [...] (793 aa)			•		0.862
	Jak1	Janus protein tyrosine kinase 1 (Fragment) (1156 aa)		•	•		0.860
	Lepr	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (CD295 antigen); The putative soluble is [...] (1165 aa)	•	•	•		0.849
	Insr	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains- Insulin receptor subun [...] (1351 aa)	•	•	•		0.846
	Irs1	Insulin receptor substrate 1 (IRS-1) (pp185); May mediate the control of various cellular proce [...] (1235 aa)		•	•		0.829

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Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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