Nbn protein (Mus musculus) - STRING network view

STRING 9.05

Nbn protein (Mus musculus) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	Nbn	nibrin Gene; Component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by [...] (751 aa)
		(Mus musculus)
Predicted Functional Partners:
	Mre11a	meiotic recombination 11 homolog A (S. cerevisiae) Gene; Component of the MRN complex, which pl [...] (706 aa)	•	•	•	•		0.999
	Rad50	RAD50 homolog (S. cerevisiae) Gene; Component of the MRN complex, which plays a central role in [...] (1312 aa)		•	•	•		0.999
	Atm	ataxia telangiectasia mutated homolog (human) Gene; Serine/threonine protein kinase which activ [...] (3066 aa)		•	•	•		0.995
	Brca1	breast cancer 1 Gene; The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathw [...] (1812 aa)		•	•	•		0.991
	H2afx	H2A histone family, member X Gene; Variant histone H2A which replaces conventional H2A in a sub [...] (143 aa)		•		•		0.839
	Mdm2	transformed mouse 3T3 cell double minute 2 Gene; Inhibits TP53/p53- and TP73/p73-mediated cell [...] (489 aa)		•		•		0.811
	Pcna	proliferating cell nuclear antigen Gene; This protein is an auxiliary protein of DNA polymerase [...] (261 aa)	•	•		•		0.744
	Mdc1	mediator of DNA damage checkpoint 1 Gene; Required for checkpoint mediated cell cycle arrest in [...] (1708 aa)		•		•		0.724
	Trp53bp1	transformation related protein 53 binding protein 1 Gene; May have a role in checkpoint signali [...] (1969 aa)		•		•	•	0.699
	Pik3cb	phosphatidylinositol 3-kinase, catalytic, beta polypeptide Gene; Phosphorylates PtdIns, PtdIns4 [...] (1064 aa)		•		•		0.691

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