STRINGSTRING
RPK2 RPK2 CLV3 CLV3 GB1 GB1 WUS WUS TPD1 TPD1 CLE40 CLE40 CLV1 CLV1 A0A1P8B502 A0A1P8B502 PLL1 PLL1 CLE17 CLE17 TMK1 TMK1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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RPK2LRR receptor-like serine/threonine-protein kinase RPK2; Key regulator of anther development (e.g. lignification pattern), including tapetum degradation during pollen maturation (e.g. germination capacity). Together with RPK1, required for pattern formation along the radial axis (e.g. the apical embryonic domain cell types that generate cotyledon primordia), and the apical-basal axis (e.g. differentiation of the basal pole during early embryogenesis). (1151 aa)    
Predicted Functional Partners:
CLV3
Protein CLAVATA 3; Extracellular signal that regulates meristem maintenance. Acts with CLV1 as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation; Belongs to the CLV3/ESR signal peptide family.
      
 0.965
GB1
Guanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Together with GCR1 and GPA1, acts as a negative regulator of ABA during seed germination and early seedling development. The heterotrimeric G-protein controls defense responses to necrotrophic and vascular fungi probably by modulating cell wall-related genes expression (e. [...]
   
 0.963
WUS
Protein WUSCHEL; Transcription factor that plays a central role during early embryogenesis, oogenesis and flowering, probably by regulating expression of specific genes. Required to specify stem cell identity in meristems, such as shoot apical meristem (SAM). May induce shoot stem cells activity in order to maintain the stem cell identity. Involved in the developmental root meristem. In shoot apices, it is sufficient to induce the expression of CLV3, a putative ligand of the CLV signaling pathway. Also required to sustain organogenesis in the floral meristem by contributing to the expr [...]
      
 0.822
TPD1
Protein TAPETUM DETERMINANT 1; Involved in cell specification during anther and pollen development. Required for the differentiation, specialization and persistence of tapetal cells in the anthers. May serve as an extracellular ligand for the EMS1 receptor kinase to signal cell fate determination during plant sexual reproduction.
      
 0.794
CLE40
CLAVATA3/ESR (CLE)-related protein 40; Extracellular signal peptide secreted by differentiated root cells that regulates root cell fate. Acts with ACR4 as a ligand- receptor pair in a signal transduction pathway, coordinating movement of the root tip and organization of cell divisions in the root meristem. Promotes cell differentiation in the distal root meristem in a dose-dependent manner, especially the transition from columella stem cells (CSC) daughters into columella cells (CCs). Induces ACR4 expression in root quiescent center (QC). Involved in WUX5 QC-specific expression pattern [...]
      
 0.794
CLV1
Receptor protein kinase CLAVATA1; Involved in the detection of CLV3 and CLV3-like (CLE) peptides, that act as extracellular signals regulating meristem maintenance. Acts with CLV3p as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  
0.776
A0A1P8B502
LRR receptor-like protein.
      
 0.775
PLL1
Protein phosphatase 2C 29; Involved in the regulation of pedicel length and of CLAVATA pathways controlling stem cell identity at shoot and flower meristems. Belongs to the PP2C family.
    
 0.755
CLE17
CLAVATA3/ESR (CLE)-related protein 17; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family.
      
 0.700
TMK1
Receptor protein kinase TMK1; Transmembrane kinase receptor. Phosphorylates only serine and threonine residues. Involved in auxin signal transduction and cell expansion and proliferation regulation. Forms with ABP1 a cell surface auxin perception complex that activates ROP signaling pathways. Required for auxin promotion of pavement cell interdigitation. Auxin promotes the formation of the ABP1-TMK1 protein complex.
  
0.698
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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