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dpf-5 dpf-5 vps-2 vps-2 ubxn-6 ubxn-6 Y67H2A.7 Y67H2A.7 dpt-1 dpt-1 kpc-1 kpc-1 tpp-2 tpp-2 istr-1 istr-1 rtfo-1 rtfo-1 dpf-3 dpf-3 dpf-7 dpf-7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
dpf-5Peptidase_S9 domain-containing protein. (737 aa)    
Predicted Functional Partners:
vps-2
Related to yeast Vacuolar Protein Sorting factor.
   
 
 0.594
ubxn-6
UBX domain-containing protein 6; Probably acts as an adapter for ATPase cdc-48.1 and/or cdc- 48.2, conferring substrate specificity. Involved in the lysosomal clearance of cellular material in diet restricted conditions.
 
 
    0.561
Y67H2A.7
Peptidase_M3 domain-containing protein.
   
 
 0.553
dpt-1
Dipeptidyl peptidase 3; Belongs to the peptidase M49 family.
   
 
 0.516
kpc-1
Furin-like protease kpc-1; Furin-like protease which cleaves proproteins at the RX(K/R)R consensus motif. During neuronal development, regulates the formation and extension of dendrite branches and cellular positioning of various type of neurons. Promotes the formation, extension and self-avoidance of dendritic branches of PVD and FLP mechanosensory neurons. In PVD neurons, regulates plasma membrane levels of branching receptor dma-1 by targeting it to late endosomes and thus promotes normal dendrite branching and dendrite self-avoidance. Also controls dendrite extension in AIY and D-t [...]
      
 0.495
tpp-2
Tripeptidyl-peptidase 2; Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity). Has a role in regulation of fat storage; Belongs to the peptidase S8 family.
   
  
 0.484
istr-1
Increased Sodium Tolerance Related.
   
   0.477
rtfo-1
RNA polymerase-associated protein RTF1 homolog; Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification.
      
 0.463
dpf-3
Dipeptidyl Peptidase Four (IV) family; Belongs to the peptidase S9B family.
  
  
 0.450
dpf-7
Dipeptidyl Peptidase Four (IV) family.
   
  
0.434
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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