CDC42 protein (Homo sapiens) - STRING interaction network

CDC42 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	CDC42	Cell division control protein 42 homolog precursor (G25K GTP-binding protein); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Causes the formation of thin, actin-rich surface projections called filopodia (191 aa)
		(Homo sapiens)
Predicted Functional Partners:
	WAS	Wiskott-Aldrich syndrome protein (WASp); Effector protein for Rho-type GTPases, providing a lin [...] (502 aa)	•	•	•	0.999
	ARHGAP1	Rho GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase p [...] (439 aa)	•	•	•	0.999
	IQGAP1	Ras GTPase-activating-like protein IQGAP1 (p195); Binds to activated CDC42 but does not stimula [...] (1657 aa)	•	•	•	0.999
	PARD6A	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction [...] (346 aa)	•	•	•	0.999
	WASL	Neural Wiskott-Aldrich syndrome protein (N-WASP); Regulates actin polymerization by stimulating [...] (505 aa)	•	•	•	0.999
	PAK1	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) [...] (553 aa)	•	•	•	0.999
	TRIP10	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10) (Protein Felic) [...] (601 aa)	•	•	•	0.999
	BAIAP2	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI- [...] (552 aa)	•	•	•	0.999
	TNK2	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2); Downs [...] (1086 aa)	•	•	•	0.999
	MAP3K11	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src- [...] (847 aa)	•	•	•	0.999

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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