PIK3R3 protein (Homo sapiens) - STRING interaction network

PIK3R3 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	PIK3R3	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK); Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1 (461 aa)
		(Homo sapiens)
Predicted Functional Partners:
	IRS1	Insulin receptor substrate 1 (IRS-1); May mediate the control of various cellular processes by [...] (1242 aa)	•	•	•	0.997
	IGF1R	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I rec [...] (1367 aa)	•	•	•	0.995
	PIK3CA	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) ( [...] (1069 aa)	•	•	•	0.987
	INSR	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains- Insulin receptor subun [...] (1382 aa)	•		•	0.968
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (P [...] (1070 aa)	•	•	•	0.963
	PTEN	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatas [...] (403 aa)	•	•	•	0.953
	IRS2	Insulin receptor substrate 2 (IRS-2); May mediate the control of various cellular processes by [...] (1338 aa)	•	•	•	0.949
	INSRR	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains [...] (1297 aa)		•	•	0.949
	PDGFRB	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b anti [...] (1106 aa)	•	•	•	0.944
	CD19	B-lymphocyte antigen CD19 precursor (Differentiation antigen CD19) (B- lymphocyte surface antig [...] (556 aa)	•	•	•	0.940

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Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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