STRINGSTRING
alp4 alp4 gtb1 gtb1 alp6 alp6 mzt1 mzt1 alp16 alp16 mod21 mod21 gfh1 gfh1 mto1 mto1 ask1 ask1 pkl1 pkl1 cut7 cut7
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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alp4Spindle pole body component alp4; Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles. Required for correct septation; Belongs to the TUBGCP family. (784 aa)    
Predicted Functional Partners:
gtb1
Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
   
 0.999
alp6
Spindle pole body component alp6; Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles; Belongs to the TUBGCP family.
   
0.999
mzt1
Mitotic-spindle organizing protein 1; Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).
   
 0.998
alp16
Spindle pole body component alp16; Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles.
    
 0.997
mod21
Gamma-tubulin complex subunit mod21; Component of the gamma-tubulin complex that is required for the regulation of both interphase microtubule organization and nucleation, and mitotic bipolar spindles. Required for correct septation.
    
 0.991
gfh1
Gamma-tubulin complex component gfh1; Required for proper anchoring of astral microtubules at the spindle pole bodies (SPBs), during anaphase, ensuring correct cell polarity; Belongs to the TUBGCP family.
    
 0.990
mto1
Microtubule organizer protein 1; Required for cytoplasmic astral microtubule growth during mitosis. Involved in localizing components of the gamma-tubulin complex to the non-spindle pole body (non-SPB) microtubule organizing centers (MTOCs). Required for new microtubule nucleation from non-SPB sites during interphase.
   
 
 0.909
ask1
DASH complex subunit ask1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. Plays a role in meiosis.
   
 
 0.892
pkl1
Kinesin-like protein 1; Microtubule-dependent motor that is involved in microtubule organization in the mitotic spindle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.
   
 
 0.890
cut7
Kinesin-like protein cut7; Could be a spindle pole body motor. On transition from G2 to M phase of the cell cycle, the spindle pole body duplicates; the daughter pole bodies seed microtubules which interdigitate to form a short spindle that elongates to span the nucleus at metaphase. Mutations at cut7 block spindle formation.
    
 
 0.875
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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