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E2f4 | Transcription factor E2F4; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole [...] (410 aa) | ||||
Zc3h8 | Zinc finger CCCH domain-containing protein 8; Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Acts as a transcriptional repressor of the GATA3 promoter. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis (By similarity). Sequence-specific DNA-binding factor that binds to the 5'- AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. (305 aa) |