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Hnf4a | Hepatocyte nuclear factor 4-alpha; Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitatating the recruitment of RNA pol II to the promoters of target genes (By similarity). Activates the transcription of CYP2C38. Represses the CLOCK-ARNTL/BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells ; Belongs to the nuclear hormone receptor family. NR2 subfamily. (474 aa) | ||||
Cyp4b1 | Cytochrome P450 4B1; Responsible for mutagenic activation of 3-methoxy-4- aminoazobenzene (3-MeO-AAB); a potent procarcinogen. Also active on 2- aminofluorene and 2-aminoanthracene; Belongs to the cytochrome P450 family. (511 aa) |