Your Input: | |||||
Cdc73 | Parafibromin; Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional [...] (531 aa) | ||||
Gsdma3 | Gasdermin-A3; May play a role in the transition from catagen to telogen at the end of hair follicle morphogenesis. May promote pyroptosis. Upon cleavage in vitro of genetically engineered Gsdma3, the released N-terminal moiety binds to membrane inner leaflet lipids, including bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to monophosphorylated phosphatidylinositols. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering p [...] (464 aa) |