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Hes1 | Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). (282 aa) | ||||
Nans | Sialic acid synthase; Produces N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) from N- acetylmannosamine 6-phosphate. Has no detectable activity towards N- acetylmannosamine or mannose 6-phosphate. (359 aa) |