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Stat4 | Signal transducer and activator of transcription 4; Carries out a dual function: signal transduction and activation of transcription. (748 aa) | ||||
Helb | DNA helicase B; 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5'- 3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dAT [...] (1074 aa) |