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Stat4 | Signal transducer and activator of transcription 4; Carries out a dual function: signal transduction and activation of transcription. (748 aa) | ||||
Nfatc2ip | NFATC2-interacting protein; In T-helper 2 (Th2) cells, regulates the magnitude of NFAT- driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly- SUMO chains by UBE2I/UBC9. (412 aa) |