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Notch1 | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2531 aa) | ||||
Cyp4b1 | Cytochrome P450 4B1; Responsible for mutagenic activation of 3-methoxy-4- aminoazobenzene (3-MeO-AAB); a potent procarcinogen. Also active on 2- aminofluorene and 2-aminoanthracene; Belongs to the cytochrome P450 family. (511 aa) |