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Acaa2 | 3-ketoacyl-CoA thiolase, mitochondrial; In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta- oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies. Also displays hydrolase activit [...] (397 aa) | ||||
Sox15 | Protein SOX-15; Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence. Acts as a transcriptional activator and repressor. Binds synergistically with POU5F1 (OCT3/4) to gene promoters. Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation. Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG. Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional a [...] (231 aa) |