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Klf9 | Krueppel-like factor 9; Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation; Belongs to the Sp1 C2H2-type zinc-finger protein family. (244 aa) | ||||
Cerk | Ceramide kinase; Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8- dihydroceramide), to a lesser extent on C2-ceramide and C6- dihydroceramide, but not on other lipids, such as various sphingosines. Shows a greater preference for D-erythro isomer of ceramides (By similarity). Binds phosphoinositides (By similarity). (531 aa) |