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Setd1a | Histone-lysine N-methyltransferase SETD1A; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression; Belongs to the class V-like SAM-binding methyltransferase superfamily. (1716 aa) | ||||
Dnajc24 | DnaJ homolog subfamily C member 24; The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron- binding. Plays a role in the diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2). (148 aa) |