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Nelfb | Negative elongation factor B; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (Pol II). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). May be able to induce chromatin unfolding (By similarity). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes. Pl [...] (631 aa) | ||||
Gpr61 | G-protein coupled receptor 61; Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity). May be involved in the regulation of food intake and body weight. (449 aa) |