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Zfp322a | Zinc finger protein 322; Transcriptional activator. Important for maintenance of pluripotency in embryonic stem cells. Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes. Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly. Promotes inhibition of MAPK signaling during embryonic stem cell differentiation. (410 aa) | ||||
Dcaf5 | DDB1- and CUL4-associated factor 5; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. (946 aa) |