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Bcl11b | B-cell lymphoma/leukemia 11B; Key regulator of both differentiation and survival of T- lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (By similarity). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes. Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. Repress tr [...] (884 aa) | ||||
Mpv17l | Mpv17-like protein; Isoform 1 and isoform 3 participate in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes; Belongs to the peroxisomal membrane protein PXMP2/4 family. (194 aa) |