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Dbp | D site-binding protein; This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation (By similarity). Belongs to the bZIP family. PAR subfamily. (325 aa) | ||||
Aqp5 | Aquaporin-5; Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands. Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa) |