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Hic2 | Hypermethylated in cancer 2 protein; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily. (619 aa) | ||||
Parp2 | Poly [ADP-ribose] polymerase 2; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP- ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'- position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (By similarity). ADP- ribosylation follows DNA damage and appears as an obligatory ste [...] (559 aa) |