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Dppa4 | Developmental pluripotency-associated protein 4; May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic stem (ES) cells into a primitive ectoderm lineage. (296 aa) | ||||
Trib1 | Tribbles homolog 1; Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase. Promotes CEBPA degradation and inhibits its function. Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain. Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner. Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. (372 aa) |