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Gata3 | Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. (443 aa) | ||||
Rdh11 | Retinol dehydrogenase 11; Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9- cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis- retinol (By similarity). Exhibits also reductive activity towards toxic lipid peroxidation products such as medium-chain aldehydes trans-2-nonenal, nonanal, and cis-6-nonenal. Has no dehydrogenase activity towards steroid. Seems to be required for homeostasis of retinol in liver and testis ; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa) |